Increased Inhibitor of Differentiation 4 (Id4) Expression in Glioblastoma: A...
Background: The inhibitor of differentiation/DNA binding protein family (Id1-4) is involved in cell cycle control, tumorigenesis and angiogenesis through the negative regulation of helix-loop-helix...
View ArticleBreast cancer heterogeneity: mechanisms, proofs, and implications
Human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically distinct subtypes with substantially different molecular and/or biochemical signatures,...
View ArticleTumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26
Retinoic Acid Receptor Responder (RARRES1) initially identified as a novel retinoic acid receptor regulated gene in the skin is a putative tumor suppressor of unknown function. RARRES1 was knocked...
View ArticleAge and tumor size predicts lymph node involvement in Hürthle Cell Carcinoma
Introduction: Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether...
View ArticleOvarian Cancer Metastatic to the Breast Presenting as Inflammatory Breast...
Background. Primary ovarian carcinoma with metastasis to the breast is rare, with only 39 cases reported in the current literature. Ovarian metastasis to the breast presenting as inflammatory breast...
View ArticleTumor cell budding from focally disrupted tumor capsules: a common pathway...
Human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically and immnohistochemically distinct subtypes with substantially different prognoses. Our...
View ArticleUndetectable and Decreased Expression of KIAA1949 (Phostensin) Encoded on...
Cytogenetic aberration and loss of heterozygosity (LOH) are documented on chromosome 6 in many cancers and the introduction of a neo-tagged chromosome 6 into breast cancer cell lines mediates...
View ArticleThe Role of 18F-FDG-Positron Emission Tomography/Computed Tomography in...
Despite Medicare approving the use of positron emission tomography/computed tomography (PET/CT) in staging primary breast cancer, little evidence is available to support the use of 18F-FDG-PET/CT for...
View ArticleBP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer
Tumor invasion and metastasis remain a major cause of mortality in breast cancer patients. It was reported that BP1, a homeobox isoform of DLX4, is overexpressed in 80% of breast cancer patients and...
View ArticleA seemingly most effective target for early detection and intervention of...
This commentary proposes that budding tumor cell projections from focally disrupted tumor capsules represent a most effective target for early detection and intervention of prostate tumor invasion....
View ArticleProtein Profiling of Isolated Leukocytes, Myofibroblasts, Epithelial, Basal,...
In situ neoplastic prostate cells are not lethal unless they become invasive and metastatic. For cells to become invasive, the prostate gland must undergo degradation of the basement membrane and...
View ArticleCancer Response Criteria and Bone Metastases: RECIST 1.1, MDA and PERCIST
Response criteria represent the standard by which the efficacy of therapeutic agents is determined in cancer trials. The most widely used criteria are based on the anatomic measurement of solid...
View ArticleDual use of a single Wilms' tumor 1 immunohistochemistry in evaluation of...
Our previous studies revealed that a single Wilms' tumor 1 (WT-1) immunohistochemistry can be used to elucidate both the myoepithelial cells and blood vessels of human breast tumors. As the human...
View ArticleChloroma/Granulocytic Sarcoma: Abdominal & Pelvic Presentation of Acute...
There is limited literature documenting granulocytic sarcoma of the colon. We report a case of a 28 year-old female with a colonic granulocystic sarcoma of the colon as a complication of AML, as it is...
View ArticleVitamin D in combination cancer treatment
As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxycholecalciferol (calcitriol) also has broad spectrum anti-tumor activities as supported by numerous...
View ArticleAdrenocortical Carcinoma and Synchronous Malignancies
Objective: Adrenocortical carcinoma (ACC) is an aggressive tumor that accounts for 0.02% of all reported cancers. ACC commonly arises in a sporadic manner, but may also manifest as part of a familial...
View ArticlePractice and Effectiveness of Outpatient Psycho-Oncological Counseling for...
Objective: Because of various types of psychological distress, cancer patients are encouraged to attend outpatient psycho-oncological and psychosocial counseling. The aim of this prospective study was...
View ArticleWT-1 expression in a spectrum of melanocytic lesions: Implication for...
A previous in vitro study revealed that Wilms's tumor 1 (WT-1) transcripts were detectable in 7 of 9 melanoma cell lines, but not in any of 5-normal melanocyte strains tested. Our current study...
View ArticleInhibition of Hypoxia-Induced Cell Motility by p16 in MDA-MB-231 Breast...
Our previous studies indicated that p16 suppresses breast cancer angiogenesis and metastasis, and downregulates VEGF gene expression by neutralizing the transactivation of the VEGF transcriptional...
View ArticleFunctional Mechanisms for Human Tumor Suppressors
Tumor suppressors refer to a large group of molecules that are capable of controlling cell division, promoting apoptosis, and suppressing metastasis. The loss of function for a tumor suppressor may...
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